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Small Molecule Drug Development

Successfully bringing a small molecule compound from late-stage discovery into the clinic requires experimentation and integration of interdependent disciplines. Wolfe Laboratories provides the highest quality translational development support, because translational research cannot be reduced to a single process—every molecule has unique chemical, pharmaceutical and business attributes. Solubility, stability and degradation pathways, solid-state properties and biopharmaceutical properties all must be characterized and analyzed an integrated fashion in late discovery/early development. With an integrated dataset, rational formulation, process development, and drug product manufacturing are streamlined.

 

Applying Wolfe Laboratories’ integrated, rational approach helps companies to identify strengths and weaknesses within compounds—allowing them to select and advance the compounds with the greatest odds of survival. Identifying the relative strengths of compounds early in the development process has enormous impact on time and cost savings. Consequently, if translational development studies are performed incorrectly the first time, it can be as costly as if they weren’t done at all.

 

The following figure provides an overview of Wolfe Laboratories’ translational capabilities for small molecules.

 

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