Wolfe Laboratories - In Vitro ADME and PK

In-vitro ADME Screens
  Aqueous Solubility
  Plasma Stability
  Protein Binding
  Microsome Stability
  CYP450
  Permeability
Pharmacokinetic Analysis
  Bioanalytical Method Development
  Biological Fluid Sample Analysis
  Tissue Analysis
Metabolite Identification

>	CASE STUDY 1 Advancement of an Early Development Candidate to Phase IIb Trials
>	CASE STUDY 2 Development of a Parenteral Formulation of a Cytotoxic Natural Product
>	CASE STUDY 3 Oral Formulation Development for Proof-of-Concept Animal Toxicology Studies
>	CASE STUDY 4 cGMP Analytical Release Testing of a Cytotoxic Drug, as Well as Other Analytical and Bioanalytical Services
>	CASE STUDY 5 Parenteral Dosage Form Development of a Highly Insoluble Molecule

In Vitro ADME and PK Support

Advancing a compound that has the right balance of properties into pre-clinical development is an important consideration for the success of any drug discovery program. In vitro ADME (absorption, distribution, metabolism and excretion) and pharmacokinetic testing can help to find those drug-like candidates. In addition to potency and selectivity, solubility, stability and permeability are important ADME factors that play an important role in determining a successful program outcome.

We understand the urgency in generating high quality data to advance your discovery programs in a timely manner and have established a core group of in vitro ADME and pharmacokinetic services to meet these needs. Our staff is dedicated to a highly interactive and collaborative relationship with our clients to assure that the individual needs of your program and the correctly customized tests are appropriately addressed.

Our modern laboratory includes ABI 4000 and ABI 4000 Q Trap™ LC-MS/MS systems that have the highest sensitivity for low level quantification.